Biological activity of binary mixtures of 2,4-D with some aminophosphonates

Abstract

A series of cyclic and acyclic aminophosphonates was synthesized for agrochem. application. The compds. differed in the substituents at the carbon, nitrogen, and phosphorus atoms. Their potential biol. activity was checked by studying their hemolytic potency, since hemolysis of erythrocytes by various compds. was found earlier to be a good indicator of their pesticidal efficiency. A series of hemolytic expts. permitted us to check the pesticidal efficiency of aminophosphonates and to det. what structural features of aminophosphonates are responsible for it. Parallelly, the authors studied the hemolytic efficiency of binary mixts. of the aminophosphonates with the well-known herbicide 2,4-dichlorophenoxyacetic acid 2,4-D... The aim was to check if potential biol. efficiencies could be enhanced in comparison with those found for individual components due to interactions between aminophosphonates and 2,4-D. An anal. of the effects binary mixts. was carried out by constructing graphs for both components of binary mixts. that give the same hemolysis (the isobole method). [on SciFinder(R)]