Pharmacogenomics of Cytauxzoon felis cytochrome b: Implications for atovaquone and azithromycin therapy in domestic cats with cytauxzoonosis

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Abstract

Cytauxzoon felis, an emerging virulent protozoan parasite that infects domestic cats, is treated with atovaquone and azithromycin (A&A). Atovaquone targets parasite cytochrome b. We characterized the C. felis cytochrome b gene (cytb) in cats with cytauxzoonosis and found a cytb genotype that was associated with survival in A&A-treated cats. Copyright © 2013, American Society for Microbiology. All Rights Reserved.

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Schreeg, M. E., Marr, H. S., Tarigo, J., Cohn, L. A., Levy, M. G., & Birkenheuer, A. J. (2013). Pharmacogenomics of Cytauxzoon felis cytochrome b: Implications for atovaquone and azithromycin therapy in domestic cats with cytauxzoonosis. Journal of Clinical Microbiology, 51(9), 3066–3069. https://doi.org/10.1128/JCM.01407-13

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