The 9-Fluorenylmethoxycarbonyl (Fmoc) Group for the Protection of Amino Functions of Cytidine, Adenosine, Guanosine and Their 2'-Deoxysugar Derivatives.

Abstract

Cytidine, adenosine, guanosine, and their 2'-deoxy derivs. on sequential trimethylsilylation, treatment with 9-fluorenylmethyl chloroformate, and hydrolysis gave the corresponding exocyclic amino group protected nucleosides in 58-90% yield. These protected nucleosides were completely deprotected within 40 min by treatment with NH3(l) in pyridine at room temp. [on SciFinder(R)]