An extended gate field-effect transistor (EG-FET) type non-enzymatic glucose sensor with inkjet-printed copper oxide nanoparticles

Abstract

Abstract: We develop a disposable and cost-effective non-enzymatic glucose sensor consisting of an extended gate field effect transistor (EG-FET) to obtain effortless operation. The sensor is fabricated by printing, gold (Au) precursor ink and copper oxide nanoparticles (CuO NPs) inks using a commercial inkjet printer on a flexible Polyimide (PI) substrate. First, sensing properties are tested electrochemically. The sensor shows a sensitivity of 728.5 μA cm−2 mM−1 and a detection limit of 0.01 mM with a correlation coefficient (R) of 0.998. The observed linear dynamic range is from 0.5 to 7 mM. After that, the sensing electrode is adapted to the EG-FET. Two linear response ranges extend from 0.1 to 4 mM of a low concentration range of glucose with a sensitivity of 1295 μA cm−2 mM−1, and from 5 to 30 mM of a high concentration range of glucose with a sensitivity of 164 μA cm−2 mM−1 are observed. The EG-FET approach can enhance the detection sensitivities using amplification for a low concentration glucose range and extending a detection range for high concentration glucose. The presented work demonstrates that simply printed CuO NPs sensors can be used at low cost for disposable wide-range glucose detection devices. Article Highlights: A non-enzymatic printed glucose sensor using an inkjet printer has been successfully developed.CuO nanoparticles ink is printed on thin gold electrodes on Polyimide film.We evaluate the glucose detection of extended-gate field-effect transistor (EG-FET) sensors.The sensitivity is estimated to be 1295 μA cm−2 mM−1.The EG-FET structure has the merit of a simple operation and cost-effective personal health care devices.