Heritable germline mutations in major cancer genes generally lead to a restricted pattern of tissue-specific malignancies, yet many of the same mutations frequently occur somatically in a broad range of spontaneous neoplasms affecting different organs. Might this reflect a difference in tumorigenesis in children and adults?.
CITATION STYLE
Maris, J. M., & Knudson, A. G. (2015, January 23). Revisiting tissue specificity of germline cancer predisposing mutations. Nature Reviews Cancer. Nature Publishing Group. https://doi.org/10.1038/nrc3894
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