2018 Uluslarası kanıta dayalı Polikistik Over Sendromu değerlendirme ve yönetim rehberi doğrultusunda uzun dönem risklerin yönetimi

Abstract

Polycystic Ovary Syndrome (PCOS); is the most common endocrine and metabolic disturbance during reproductive period in women. Although its high prevalence, different phenotypes, heterogeneous clinic presentations related to age and ethnical differences; result in diagnostic dilemmas for both the clinicians and the patients. The exact pathophsiology of PCOS is yet to be defined. PCOS is thought to be a multi-systemic disease currently. In any case, both insulin resistance and hyperandrogenemia, and the presence of both conclude with an increased long-term risk of patients for obesity, dyslypidemi, insulin resistance with compensatuar hyperinsulinemia, metabolic syndrome and cardiovascular diseases. Reproductive, metabolic, systemic, or psychological effects of PCOS may come into prominence separately in different periods of life. Although the comorbidities of PCOS are mostly known, the algorithms related to optimal screening, total risk assessment, and clinical management are still controversial for comorbidities in this patient group. While the diagnosis and treatment planning for the complaints, the heterogeneous nature of the disease is generally ignored, and there is often insufficient consultation on the comorbidities and long-term risks of the disease. However there is a marked clinical variation in the course of the disease throughout life, medical problems associated with PCOS may reappear with additional comorbidities in the chronic process. The aim of this review is to examine the recommendations with respect to the 2018 International Evidence Based PCOS Assessment and Management Guideline (2018 PCOS Guideline) in terms of concomitant co morbid diseases and long-term risks related to PCOS.