Association between type A blaZ gene polymorphism and cefazolin inoculum effect in methicillin-susceptible Staphylococcus aureus

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Abstract

Some proportion of type A blaZ gene-positive methicillin-susceptible Staphylococcus aureus strains exhibit the cefazolin inoculum effect (CIE). The type A blaZ gene was divided into two groups by single nucleotide polymorphisms (SNPs) at Ser226Pro and Cys229Tyr. The median cefazolin MICs at a high inoculum concentration were 5.69 μg/ml for the Ser-Cys group and 40.32 μg/ml for the Pro-Tyr group (P = 0.01). The SNPs at codons 226 and 229 in the amino acid sequence encoded by the blaZ gene were closely associated with the CIE.

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Lee, S. H., Park, W. B., Lee, S., Park, S., Kim, S. W., Lee, J. M., … Oh, M. D. (2016). Association between type A blaZ gene polymorphism and cefazolin inoculum effect in methicillin-susceptible Staphylococcus aureus. Antimicrobial Agents and Chemotherapy, 60(11), 6928–6932. https://doi.org/10.1128/AAC.01517-16

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