Advancements in Managing Choledocholithiasis and Acute Cholangitis in the Elderly: A Comprehensive Review

Abstract

The increasing elderly population has led to a rising prevalence of choledocholithiasis and acute cholangitis, presenting unique diagnostic and therapeutic challenges owing to age-related physiological changes and multiple comorbidities. This comprehensive review synthesizes current evidence and recent advances in managing these conditions in elderly patients, with a particular focus on diagnostic innovations, therapeutic strategies, and perioperative optimization. Recent advances in diagnostic modalities, including enhanced imaging techniques and AI-assisted systems, have improved early detection accuracy, whereas minimally invasive interventions, particularly endoscopic retrograde cholangiopancreatography (ERCP) and laparoscopic common bile duct exploration (LCBDE), have demonstrated superior outcomes when combined with comprehensive perioperative care. The implementation of multidisciplinary approaches and personalized treatment strategies has significantly improved patient outcomes, with evidence supporting the critical role of early antibiotic intervention, careful surgical selection, and enhanced recovery protocols in reducing morbidity and mortality. The optimal management of elderly patients with choledocholithiasis and acute cholangitis requires a systematic, individualized approach incorporating advanced diagnostic techniques, minimally invasive interventions, and comprehensive perioperative care, while future research should focus on developing age-specific treatment algorithms and validating novel therapeutic approaches.