Protective Effect of Maternal Prebiotics Against Neonatal Jaundice Induced by Phenylhydrazine in Rats

Abstract

Background and Objective: The nutritional environment in utero renders defensive mechanism in the neonates. Hence, the present study was framed to elucidate the protective effect of maternal prebiotics administration in neonatal jaundice. Material(s) and Method(s): Rats pups of Wistar strain were fed prebiotic fiber diet, oligofructose (40%, (w/w), ad libitum) throughout pregnancy and lactation was induced with jaundice by intraperitoneal injection of phenylhydrazine hydrochloride (50 mg kgG1 b.wt., dissolved in saline). At the end of the experimental period, the pups were killed, blood samples and liver tissues were isolated and tested for various oxidative markers, anti-oxidant enzymes, serum markers such as; bilirubin and SGOT, SGPT and liver function marker enzymes. Result(s): The offspring's of maternal prebiotics administration renders protective effect in liver enzyme markers such as; ALP, SGOT and SGPT which was demonstrated by the unaltered levels of the enzymes compared to jaundice group. In addition, cellular metabolizing enzymes such as; SDH, GDH, GGT were also restored with reduced oxidative markers and improved antioxidant enzymes compared to jaundice induced rats. Conclusion(s): Thus, the study demonstrated that the supplementation of maternal diet with the prebiotic fiber oligofructose elicits a long-term beneficial effect in offsprings in terms of hepatoprotection.Copyright © 2019 Jinting Liu and Shuangping Zhen.