Acquired transmissibility of sheep-passaged L-type bovine spongiform encephalopathy prion to wild-type mice

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Abstract

L-type bovine spongiform encephalopathy (L-BSE) is an atypical form of BSE that is transmissible to cattle and several lines of prion protein (PrP) transgenic mice, but not to wild-type mice. In this study, we examined the transmissibility of sheep-passaged L-BSE prions to wild-type mice. Disease-associated prion protein (PrPSc) was detected in the brain and/or lymphoid tissues during the lifespan of mice that were asymptomatic subclinical carriers, indicating that wild-type mice were susceptible to sheep-passaged L-BSE. The morphological characteristics of the PrPSc of sheep-passaged L-BSE included florid plaques that were distributed mainly in the cerebral cortex and hippocampus of subsequent passaged mice. The PrPSc glycoform profiles of wild-type mice infected with sheep-passaged L-BSE were similar to those of the original isolate. The data indicate that sheep-passaged L-BSE has an altered host range and acquired transmissibility to wild-type mice.

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Okada, H., Masujin, K., Miyazawa, K., & Yokoyama, T. (2015). Acquired transmissibility of sheep-passaged L-type bovine spongiform encephalopathy prion to wild-type mice. Veterinary Research, 46(1). https://doi.org/10.1186/s13567-015-0211-2

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