Transfusion therapy

Abstract

The decision to transfuse blood and blood components should be based on an assessment of the risks and benefits of such treatment, as well as on the availability and relative effectiveness of alternative therapies. Although a large amount of information regarding the known risks of transfusion is available, objective information about the indications and benefits of transfusion is not as extensive or as readily quantified. Because data on indications are not definitive, transfusion practice is not standardized. Consequently, patients may either be under-transfused or over-transfused. A number of “expert panel” and consensus conference guidelines on transfusion therapy have been published (1-4). Although these publications are useful aids, they should not serve as a substitute for clinical judgment in the transfusion decision-making process.