Application of Droplet Digital PCR Technology in Muscular Dystrophies Research

5Citations
Citations of this article
65Readers
Mendeley users who have this article in their library.

Abstract

Although they are considered rare disorders, muscular dystrophies have a strong impact on people’s health. Increased disease severity with age, frequently accompanied by the loss of ability to walk in some people, and the lack of treatment, have directed the researchers towards the development of more effective therapeutic strategies aimed to improve the quality of life and life expectancy, slow down the progression, and delay the onset or convert a severe phenotype into a milder one. Improved understanding of the complex pathology of these diseases together with the tremendous advances in molecular biology technologies has led to personalized therapeutic procedures. Different approaches that are currently under extensive investigation require more efficient, sensitive, and less invasive methods. Due to its remarkable analytical sensitivity, droplet digital PCR has become a promising tool for accurate measurement of biomarkers that monitor disease progression and quantification of various therapeutic efficiency and can be considered a tool for non-invasive prenatal diagnosis and newborn screening. Here, we summarize the recent applications of droplet digital PCR in muscular dystrophy research and discuss the factors that should be considered to get the best performance with this technology.

Cite

CITATION STYLE

APA

Lambrescu, I., Popa, A., Manole, E., Ceafalan, L. C., & Gaina, G. (2022, May 1). Application of Droplet Digital PCR Technology in Muscular Dystrophies Research. International Journal of Molecular Sciences. MDPI. https://doi.org/10.3390/ijms23094802

Register to see more suggestions

Mendeley helps you to discover research relevant for your work.

Already have an account?

Save time finding and organizing research with Mendeley

Sign up for free