Marrow assessment for hemophagocytic lymphohistiocytosis demonstrates poor correlation with disease probability

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Abstract

Objectives: To evaluate the amount of hemophagocytosis in 64 marrow core biopsy specimens and aspirates from 58 patients with clinical suspicion for secondary hemophagocytic lymphohistiocytosis (HLH) or reported findings of hemophagocytosis. Methods: A review of medical records assigned patients to a low-risk (45 patients) or high-risk (13 patients) HLH group, and association with histologic findings was examined using the Fisher exact test. Results: The amount of hemophagocytosis in aspirate or the core biopsy specimen did not correlate with disease probability (P = .17 and P = .63, respectively). Of the clinical/laboratory criteria assessed, the most significant correlations with HLH were highly elevated ferritin (P = .01), cytopenias (P = .02), and fever (P = .009). Conclusions: Our findings indicated that marrow histologic findings alone do not reliably predict the probability of HLH, and an isolated finding of hemophagocytosis, even when present in a high amount, lacks specificity for HLH. © American Society for Clinical Pathology.

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APA

Ho, C., Yao, X., Tian, L., Li, F. Y., Podoltsev, N., & Xu, M. L. (2014). Marrow assessment for hemophagocytic lymphohistiocytosis demonstrates poor correlation with disease probability. American Journal of Clinical Pathology, 141(1), 62–71. https://doi.org/10.1309/AJCPMD5TJEFOOVBW

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