Computer Aided Drug Design for finding a therapeutics for Dengue Virus Targets

Abstract

The dengue epidemic has taken aback the entire world today. It affects millions of people worldwide sometimes causing severe manifestation, affecting body metabolomics. It’s caused by an arthropod-bornesingle-stranded RNA virus that has been distributed across the coastal regions of the globe with the advent of commercialization and trade. There is no effective treatment for dengue till date, but different forms of anti-viral vaccines are in the process of clinical trials for human use. Computational methods are being developed to unravel the viral transmission mechanics and evolution. Numerous networking models are being proposed to understand the phylogeny and inheritance pattern of the virus. Data models are projected in terms of mechanics or statistics to consider the distribution pattern of dengue in the future. This article talk about dengue virus targets at its genomics level.Several case scenario of applying CADD tools for finding the lead molecule for dengue targets were discussed. Advancement in dengue research with recent developments in computational methods were analyzed. The outcome of the present study suggested advancement in computational approaches may offer focused development of drugs for dengue.