Epigenetics in alternative pre-mRNA splicing

486Citations
Citations of this article
1.3kReaders
Mendeley users who have this article in their library.

Abstract

Alternative splicing plays critical roles in differentiation, development, and disease and is a major source for protein diversity in higher eukaryotes. Analysis of alternative splicing regulation has traditionally focused on RNA sequence elements and their associated splicing factors, but recent provocative studies point to a key function of chromatin structure and histone modifications in alternative splicing regulation. These insights suggest that epigenetic regulation determines not only what parts of the genome are expressed but also how they are spliced. © 2011 Elsevier Inc.

Cite

CITATION STYLE

APA

Luco, R. F., Allo, M., Schor, I. E., Kornblihtt, A. R., & Misteli, T. (2011, January 7). Epigenetics in alternative pre-mRNA splicing. Cell. https://doi.org/10.1016/j.cell.2010.11.056

Register to see more suggestions

Mendeley helps you to discover research relevant for your work.

Already have an account?

Save time finding and organizing research with Mendeley

Sign up for free