Synthesis and pharmacological evaluation of some phenylpyrazolo indoquinoxaline derivatives

Abstract

Indoloquinoxalin was fused with 2,3 diphenyl quinoxaline by a methylene bridge which was then allowed for acetylation. The acetylated product was made to react with different aromatic aldehydes to give chalcones. Chalcones refluxed with substituted acid hydrazides to afford different indoloquinoxaline pyrazolines. The structure of chalcones andindoloquinoxaline pyrazolines were confirmed by M.P, TLC and spectral data. All the synthesized compounds were screened for their antioxidant, antiinflammatory and antihistamic activities. © Copyright E-Journal of Chemistry 2004-2011.