Multifunctional roles for the protein translocation machinery in rna anchoring to the endoplasmic reticulum

Abstract

Background: ER-localized mRNAs are anchored to the ER via their functional engagement with translocon-bound ribosomes. Results: Ribosome-engaged mRNAs are ER-bound through distinct and mRNA-selective mechanisms. Conclusion: Multiple ER membrane proteins, including the Sec61 complex, display RNA binding activity and anchor select mRNAs to the ER. Significance: These data reveal new functions for the translocation machinery and advance understanding of RNA localization to the ER.