Razão TG/HDL-c, indicadores antropométricos e bioquímicos de risco cardiovascular no renal crônico em tratamento conservador

Abstract

Introduction: Cardiovascular diseases (CVD) are a major cause of morbidity and mortality, and its prevalence is growing worldwide. Patients with chronic kidney disease (CKD) are at high risk of group, especially those with dyslipidemia. Triglycerides (TG) and high-density lipoprotein (HDL-c) are independent predictors of cardiovascular events. Excessive adipose tissue also increases the cardiovascular risk. Therefore, CVD predictors, such as the Triglycerides/HDL cholesterol (TG/HDL-c) ratio and the anthropometric measurements for assessing body fat are important in clinical practice. Objective: To evaluate the association between TG/HDL ratio, anthropometric measurements and the cardiovascular risk in CKD patients on dialysis. Methods: A cross-sectional study involving 90 clinically stable outpatients. The TG/HDL-c ratio was defined according to a predetermined equation, considering high CVD risk values greater than 2.5 for women and greater than 3.5 for men. The anthropometric parameters used were the body mass index (BMI) and the waist circumference (WC). Social data, lifestyle, clinical and biochemical data were also collected. Results: Fifty patients (55.6%) had a high TG/HDL ratio. Patients with abnormal BMI and WC were at a higher cardiovascular risk, as measured by the TG/HDL-c ratio. There was a statistically significant difference between the anthropometric measurements (BMI and the WC), and the TG/HDL-c ratio in the stratified analysis. However, in the adjusted analysis no association between the BMI or the WC and the TG/HDL ratio was observed. Conclusion: There was no association between the TG/HDL-C ratio and the adiposity measurements (BMI and WC) in the adjusted analysis. The results of this study question the real influence of overweight and central obesity in the TG/HDL-c ratio.