Abstract
(Chemical Equation Presented) Marginally stable natural products: The asymmetric total synthesis of the hydrolytically and thermally labile natural product (+)-isomigrastatin was demonstrated. The thermodynamic instability of a 2E-configured double bond in the context of this 12-membered macrolide was further demonstrated by phosphine-catalyzed isomerization to the 2Z configuration. © 2007 Wiley-VCH Verlag GmbH & Co. KGaA.
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Krauss, I. J., Mandal, M., & Danishefsky, S. J. (2007). Total synthesis of (+)-isomigrastatin. Angewandte Chemie - International Edition, 46(29), 5576–5579. https://doi.org/10.1002/anie.200701837
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