Site-specific conjugation of single domain antibodies to liposomes enhances photosensitizer uptake and photodynamic therapy efficacy

M. Broekgaarden; R. Van Vught; S. Oliveira; R. C. Roovers; P. M.P. Van Bergen En Henegouwen; R. J. Pieters; T. M. Van Gulik; E. Breukink; M. Heger

Journal ArticleOPEN ACCESS

Site-specific conjugation of single domain antibodies to liposomes enhances photosensitizer uptake and photodynamic therapy efficacy

Nanoscale (2016) 8(12) 6490-6494

DOI: 10.1039/c6nr00014b

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Abstract

Photodynamic therapy for therapy-resistant cancers will greatly benefit from targeted delivery of tumor photosensitizing agents. In this study, a strategy for the site-specific conjugation of single domain antibodies onto liposomes containing the photosensitizer zinc phthalocyanine was developed and tested.

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Broekgaarden, M., Van Vught, R., Oliveira, S., Roovers, R. C., Van Bergen En Henegouwen, P. M. P., Pieters, R. J., … Heger, M. (2016). Site-specific conjugation of single domain antibodies to liposomes enhances photosensitizer uptake and photodynamic therapy efficacy. Nanoscale, 8(12), 6490–6494. https://doi.org/10.1039/c6nr00014b

Site-specific conjugation of single domain antibodies to liposomes enhances photosensitizer uptake and photodynamic therapy efficacy

Abstract

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