β-casomorphin-7: a review of occurrence, identification, techno-functionality, and effects on human health

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Abstract

β-casomorphin-7 (βCM-7) is a bioactive peptide released after the digestion of β-casein A1 variant, mostly found in European cow breeds’ milk. This review explores the occurrence, characteristics, identification, techno-functionality, and the potential health effects of βCM-7. It displays opioid-like properties because of its affinity for μ-opioid receptors, affecting both food texture and biological functions. βCM-7 has potential advantages on immune and gastrointestinal health; however, concerns persist regarding its adverse effects.

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Ali, A. H., Hachem, M., Najjar, Z., Liu, S. Q., Bamigbade, G. B., & Ayyash, M. (2026, December 1). β-casomorphin-7: a review of occurrence, identification, techno-functionality, and effects on human health. Npj Science of Food. Nature Research. https://doi.org/10.1038/s41538-026-00762-2

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