Pleuromutilins fermentation, structure and biosynthesis

Abstract

Derivatives of pleuromutilin, formed during the fermentation of pleuromutilin were isolated and their structure determined. 14-Acetyl-mutilin and mutilin as well as different unsaturated fatty acid esters of pleuromutilin were identified. The proportion of each derivative formed depends to a considerable degree on the conditions of the fermentation process. The possible biosynthetic pathways are shown. © 1976, JAPAN ANTIBIOTICS RESEARCH ASSOCIATION. All rights reserved.