Ubiquitin binding domains - from structure to application

Abstract

Ubiquitin is one of the most important signal molecular in biological process and ubiquitination plays essential roles in many signal transduction pathways. In most cases, they function as a post transcription modification on target protein as a monomer or a chain, which could recruit other protein with ubiquitin binding domains (UBDs) to enable signal transduction. The UBDs are variant on structure and recognition site on ubiquitin. For the variant function the UBDs gives, UBDs are good tools pool for material design such as ubiquitin pathway inhibitor, ubiquitin enrichment material and manufactural specific ubiquitin chain antibody. In this review, we summarize some recent work on UBDs characterization and application.