Predictive model for cytoneme guidance in Hedgehog signaling based on Ihog- Glypicans interaction

8Citations
Citations of this article
17Readers
Mendeley users who have this article in their library.

This article is free to access.

Abstract

During embryonic development, cell-cell communication is crucial to coordinate cell behavior, especially in the generation of differentiation patterns via morphogen gradients. Morphogens are signaling molecules secreted by a source of cells that elicit concentration-dependent responses in target cells. For several morphogens, cell-cell contact via filopodia-like-structures (cytonemes) has been proposed as a mechanism for their gradient formation. Despite of the advances on cytoneme signaling, little is known about how cytonemes navigate through the extracellular matrix and how they orient to find their target. For the Hedgehog (Hh) signaling pathway in Drosophila, Hh co-receptor and adhesion protein Interference hedgehog (Ihog) and the glypicans Dally and Dally-like-protein (Dlp) interact affecting the cytoneme behavior. Here, we describe that differences in the cytoneme stabilization and orientation depend on the relative levels of Ihog and glypicans, suggesting a mechanism for cytoneme guidance. Furthermore, we have developed a mathematical model to study and corroborate this cytoneme guiding mechanism.

Cite

CITATION STYLE

APA

Aguirre-Tamaral, A., Cambón, M., Poyato, D., Soler, J., & Guerrero, I. (2022). Predictive model for cytoneme guidance in Hedgehog signaling based on Ihog- Glypicans interaction. Nature Communications, 13(1). https://doi.org/10.1038/s41467-022-33262-4

Register to see more suggestions

Mendeley helps you to discover research relevant for your work.

Already have an account?

Save time finding and organizing research with Mendeley

Sign up for free