Autophagy induction by histone deacetylase inhibitors inhibits HIV type 1

Abstract

Background: Histone deacetylase inhibitors are being evaluated to induce latent HIV reactivation, but their effect on macrophages is unknown. Results: Histone deacetylase inhibitors induce the degradation of HIV in macrophages through a mechanism that involves autophagosome formation and maturation. Conclusion: Histone deacetylase inhibitors inhibit HIV through an autophagy-dependent mechanism. Significance: This is the first report of histone deacetylase inhibitors inhibiting HIV.