Synthesis and reactivity of [1,2,4]triazolo-annelated quinazolines

Abstract

This paper reports the synthesis of phenyl-substituted 2- alkoxy(methylsulfanyl)- 1,2,4-triazolo[1,5-a]quinazolines starting from N-cyanoimidocarbonates and substituted hydrazinobenzoic acids as building blocks. Thionation or chlorination of the inherent lactam moiety in the target compounds followed by treatment with multifunctional nucleophiles provided access to a variety of derivatives. © 2010 by the authors.