Protein-Localized Bright-Red Fluorescent Gold Nanoclusters as Cyanide-Selective Colorimetric and Fluorometric Nanoprobes

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Abstract

Herein, we describe a bright-red-emitting ovalbumin-protected gold nanoclusters (OVA-AuNCs) that were prepared and applied as a luminescent probe for a simple, rapid, and highly sensitive determination of cyanide ions (CN- ions) based on an emission quenching and colorimetric method. Initially, an intense red-emissive fluorescence of the OVA-AuNCs successfully disappeared upon the addition of CN- ions. The resultant emission-quenching process involved CN- ions etching the OVA-AuNC surface, which produced AuCN2- complexes in the presence of ambient oxygen. Under optimized experimental conditions, the relative emission intensity is inversely relative to CN- ion concentrations ranging from 5.00 × 10-7 to 75.00 × 10-7 mol/L with a linear correlation coefficient of 0.9932. Furthermore, OVA-AuNC-based optical detection systems on both colorimetric and fluorometric assays were tested, which expose highly sensitive and specific determination of CN- ions, and it is easily visualized by the naked eye (day light and UV light). Because of the distinct Elsner reaction between Au atoms of OVA-AuNCs and CN- ions, the recent nanoprobe offered ultrasensitivity and good selectivity with the lowest limit of detection value of 68.00 × 10-9 mol/L. In addition, this fluorescence "turn-off" CN- ion detection method was executed in real water samples. The demonstrated route of OVA-AuNC preparation is extremely easy and quick, making the proposed selective and sensitive CN- ion sensing assay based on the fluorescence response of the OVA-AuNCs for numerous practical applications.

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Rajamanikandan, R., & Ilanchelian, M. (2018). Protein-Localized Bright-Red Fluorescent Gold Nanoclusters as Cyanide-Selective Colorimetric and Fluorometric Nanoprobes. ACS Omega, 3(10), 14111–14118. https://doi.org/10.1021/acsomega.8b02044

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