Closing in on a mechanism for activation

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Abstract

When insulin-like growth factor-1 (IGF1) binds to its receptor, a physical constraint is released that allows the two transmembrane helices to come together to facilitate activation of the receptor.

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Hubbard, S. R., & Miller, W. T. (2014). Closing in on a mechanism for activation. ELife, 3. https://doi.org/10.7554/eLife.04909

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