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Xnr4: A Xenopus nodal-related gene expressed in the Spemann organizer

Developmental Biology (1997) 184(2) 367-372
DOI: 10.1006/dbio.1997.8510
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Abstract

We have isolated a novel TGFβ-like gene from Xenopus which is highly related to mouse nodal. The gene, Xnr4, is expressed at the gastrula stage in the Spemann organizer and at later stages in the notochord and neural tube. Ectopic expression of Xnr4 can induce and dorsalize mesoderm. These studies suggest that Xnr4, along with other nodal-related genes (Xnr1-3), may participate in mesodermal patterning and possibly neural development.

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Joseph, E. M., & Melton, D. A. (1997). Xnr4: A Xenopus nodal-related gene expressed in the Spemann organizer. Developmental Biology, 184(2), 367–372. https://doi.org/10.1006/dbio.1997.8510

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