High temporal resolution BOLD responses to visual stimuli measured in the mouse superior colliculus

Abstract

Line-scanning fMRI offers the opportunity to measure bloodoxygenleveldependent (BOLD) signals at sub-second temporal resolution, by sacrificing the acquisition of a 3D image. This work demonstrates its first application to the mouse brain, measuring BOLD responses to a visual stimulus in the superior colliculus with a repetition time of 200 ms. This work is an important step in matching mouse BOLD signal data with 2D optical imaging spectroscopy studies measuring high-temporal-resolution haemodynamics and may prove useful for haemodynamic modelling.