Study the Arginase Activity and Its Correlation with Liver and Kidney Functions for Patients with Type-2 Diabetes Mellitus in Nineveh Governorate

Abstract

Background: Arginase plays an essential role in type 2 diabetes mellitus.. Aim of the study: The study aimed to determine the activity of arginase in individuals patients with diabetes mellitus type 2 (DMT2) and study the correlation between arginase activity and the investigated variables Patients and material methods: The study included 201 adults divided into two groups: those with DMT2 (136 people) and control groups (65 people). Blood non-fasting persons had their determination of arginase activity, glucose, glycated haemoglobin (HbA1c), alanine aminotransferase (ALT), aspartate aminotransferase (AST), urea, and creatinine levels . Results: The findings showed that the level of arginase activity in patients with DMT2 was significantly increased (p≤0.0001) in comparison with control groups, but there was no significant differentiation in the activity of arginase for both gender and age. A positive significant correlation (P=0.01) was found between Glucose (r=0.584), HbA1c (r=0.454), AST(GOT) (r=0.433), ALT (GPT) (r=0.295), ALP (r=0.639), Urea (r=0.667), and Creatinine (r=0.658). Conclusion: In patients with DMT2, increase the activity of arginase plays an active role through it is direct effect on liver and kidney functions.