Comparative study on efficacy of myo inositol over metformin in Polycystic ovary syndrome patients

Abstract

Background: Study aimed to determine the effectiveness of Myo-Inositol over Metform in women with established diagnosis of PCOS. Method: A total of 90 women diagnosed with PCOS with Vitamin D deficiency included in the study and divided into 3 groups of 30 each. Group A received Tab. Metformin 500mg thrice daily for a period of 24 wks. Group B women received Tab. Myoinositol 2 gm twice daily for a period of 24 wks. Group C women received Tab. Metformin 500mg twice daily with Tab. Myoinositol 2 gm twice daily. Results: After treatment, 26%, 50%, and 80% were showed regular menstrual cycles (p= 0.001).  After 6 months of treatment, there was a reduction of polycystic ovaries in 50% in group A, 80% reduction in group B, and 93.33% reduction in group C respectively. There was a significant reduction in Acne, Hirusitism, BMI, serum LH, FSH, LH/FSH ratio, free testosterone, total testosterone, serum insulin levels, total cholesterol levels were seen at the end of 24 weeks in 3 groups, but higher significance seen in group C. Conclusion: It is thus evident that Myoinositol administration helps to improve insulin sensitivity and can be used in women with PCOS having insulin resistance. Myoinositol helps in reducing metabolic and endocrine abnormalities in PCOS patients. Myoinositol is safe, inexpensive and easily available, its addition to Metformin can contribute for normalization of the dysregulated metabolism in various tissues including ovaries, pancreas, muscle and enhance the action of Metformin in improving the clinical, biochemical features of PCOS.