Cochlioquinone a, a nematocidal agent which competes for specific (3H)ivermectin binding sites

James M. Schaeffer; Easter G. Frazier; Alan R. Bergstrom; Joanne M. Williamson; Jerrold M. Liesch; Michael A. Goetz

Journal ArticleOPEN ACCESS

Cochlioquinone a, a nematocidal agent which competes for specific (3H)ivermectin binding sites

Schaeffer J
Frazier E
Bergstrom A
et al.

The Journal of Antibiotics (1990) 43(9) 1179-1182

DOI: 10.7164/antibiotics.43.1179

28Citations

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Abstract

Cochlioquinone A, isolated from the fungus Helminthosporium sativum, was found to have nematocidal activity. Cochlioquinone A is a competitive inhibitor of specific [3H]ivermectin binding suggesting that cochlioquinone A and ivermectin interact with the same membrane receptor. © 1990, JAPAN ANTIBIOTICS RESEARCH ASSOCIATION. All rights reserved.

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Schaeffer, J. M., Frazier, E. G., Bergstrom, A. R., Williamson, J. M., Liesch, J. M., & Goetz, M. A. (1990). Cochlioquinone a, a nematocidal agent which competes for specific (3H)ivermectin binding sites. The Journal of Antibiotics, 43(9), 1179–1182. https://doi.org/10.7164/antibiotics.43.1179

Cochlioquinone a, a nematocidal agent which competes for specific (3H)ivermectin binding sites

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