Recent advances in aryl–aryl bond formation by direct arylation

Citations of this article
Mendeley users who have this article in their library.
Get full text


The abundance of the biaryl structural motif in natural products, in biologically active molecules and in materials chemistry has positioned aryl–aryl (Ar–Ar) bond formation high on the agenda of synthetic chemists. For decades well-known reactions such as the Mizoroki–Heck and Suzuki–Miyaura have been the methods of choice to furnish biaryls. More recently, however, alternative methods, most notably direct arylation via C–H activation, have become the focus of many research groups. Compared to traditional methods, direct arylation affords Ar–Ar compounds in fewer steps by removing the need for prefunctionalisation. Furthermore, given that either one or two hydrogens are targeted, less waste and good atom economy are features of this methodology. This critical review covers, in the main part, reports from January 1, 2006, to October 22, 2008 (117 references). © 2009 The Royal Society of Chemistry.




Mc Glacken, G. P., & Bateman, L. M. (2009). Recent advances in aryl–aryl bond formation by direct arylation. Chemical Society Reviews, 38(8), 2447–2464.

Register to see more suggestions

Mendeley helps you to discover research relevant for your work.

Already have an account?

Save time finding and organizing research with Mendeley

Sign up for free