Qualitative anti-tubercular activity of synthetic ethyl 7-acetyl- 2-substituted-3-(4-substituted benzoyl) indolizine-1-carboxylate analogues

Abstract

Both the emergence of multidrug-resistant and extensively drug-resistant tuberculosis (TB) are currently the major challenges in the treatment of TB. Only delamanid and bedaquiline have been recently approved as anti-TB drugs in the past 40 years. In an attempt to search for active anti-TB compounds against the sensitive strain of Mycobacterium tuberculosis, H37Rv-a series of synthetic ethyl 7-acetyl-2-substituted-3-(4-substituted benzoyl)indolizine-1- carboxylates (2a-r)-have been screened for in vitro qualitative anti-TB activity using an agar dilution method. It was found that compounds 2a, 2b, 2c, 2f, 2g, 2i, 2j, 2l, 2o, 2p, and 2r, which have various functional groups on the indolizine nucleus, were active against the H37Rv strain.