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Intrapatient emergence of OXA-247: A novel carbapenemase found in a patient previously infected with OXA-163-producing Klebsiella pneumoniae

Clinical Microbiology and Infection (2013) 19(5)
DOI: 10.1111/1469-0691.12142
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Abstract

Two genetically related Klebsiella pneumoniae strains carrying OXA-type carbapenemases were isolated from a single patient 1 month apart. Kpn163 harboured OXA-163 and Kpn247 a new variant named OXA-247 that showed susceptibility to carbapenems and expanded-spectrum cephalosporins similar to OXA-48. Our epidemiological, biochemical and molecular results suggest the intrapatient emergence of blaOXA-247 from blaOXA-163. © 2013 The Authors. Clinical Microbiology and Infection © 2013 European Society of Clinical Microbiology and Infectious Diseases.

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Gomez, S., Pasteran, F., Faccone, D., Bettiol, M., Veliz, O., De Belder, D., … Corso, A. (2013). Intrapatient emergence of OXA-247: A novel carbapenemase found in a patient previously infected with OXA-163-producing Klebsiella pneumoniae. Clinical Microbiology and Infection, 19(5). https://doi.org/10.1111/1469-0691.12142

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