The impact of super-spreaders in COVID-19: Mapping genome variation worldwide

0Citations
Citations of this article
55Readers
Mendeley users who have this article in their library.
Get full text
This PDF is freely available from an open access repository. It may not have been peer-reviewed.

Abstract

The human pathogen severe acute respiratory syndrome coronavirus 2 (SARSCoV-2) is responsible for the major pandemic of the 21st century. We analyzed >4,700 SARS-CoV-2 genomes and associated meta-data retrieved from public repositories. SARS-CoV-2 sequences have a high sequence identity (>99.9%), which drops to >96% when compared to bat coronavirus. We built a mutation-annotated reference SARS-CoV-2 phylogeny with two main macro-haplogroups, A and B, both of Asian origin, and >160 sub-branches representing virus strains of variable geographical origins worldwide, revealing a uniform mutation occurrence along branches that could complicate the design of future vaccines. The root of SARS-CoV-2 genomes locates at the Chinese haplogroup B1, with a TMRCA dating to 12 November 2019 - thus matching epidemiological records. Sub-haplogroup A2a originates in China and represents the major non-Asian outbreak. Multiple founder effect episodes, most likely associated with super-spreader hosts, explain COVID-19 pandemic to a large extent.

Cite

CITATION STYLE

APA

Gómez-Carballa, A., Bello, X., Pardo-Seco, J., Martinón-Torres, F., & Salas, A. (2020, May 19). The impact of super-spreaders in COVID-19: Mapping genome variation worldwide. BioRxiv. bioRxiv. https://doi.org/10.1101/2020.05.19.097410

Register to see more suggestions

Mendeley helps you to discover research relevant for your work.

Already have an account?

Save time finding and organizing research with Mendeley

Sign up for free