Case - Fungal urosepsis after ureteroscopy in a patient on new generation of antihyperglycemic medication

Abstract

Diabetes mellitus is a growing disease with extensive health risks.1 Gliflozin represents a new class of medications in the treatment armamentarium for diabetes. Medications in this class include dapagliflozin, canagliflozin, and empag­liflozin. Their primary mechanism of action is blocking sodium-glucose transporter protein 2 (SGLT)-2, which inhib­its the reabsorption of glucose in the kidney, and therefore lowers systemic blood sugar levels.2 SGLT-2 inhibitors are known to have higher urinary glucose levels as a byproduct of lowering blood glucose levels. Not surprisingly, patients on gliflozins have an increased incidence of urinary tract infections (UTIs), likely due to the associated glucosuria from the medication.