Von Willebrand factor (VWF) is considered a reliable marker of endothelial damage. Plasma levels of VWF were measured in 857 middle-aged subjects (80.4% men) free of clinically overt atherosclerotic disease, in relation to cardiovascular risk factors, carotid intima-media thickness (IMT) and microalbuminuria, two established surrogate markers of atherosclerosis. There was linear trend for the increase of VWF, carotid IMT (p < 0.001) and microalbuminuria (p = 0.018). The association between VEF and both markers remained statistically significant after adjusting for cardiovascular risk factors and inflammatory markers (p < 0.01). In conclusion, VWF was independently associated with both structural and functional surrogates of atherosclerosis in asymptomatic subjects, thus representing a systemic biomarker of subclinical atherosclerosis. © 2005 International Society on Thrombosis and Haemostasis.
CITATION STYLE
Páramo, J. A., Beloqui, O., Colina, I., Diez, J., & Orbe, J. (2005, April). Independent association of von Willebrand factor with surrogate markers of atherosclerosis in middle-aged asymptomatic subjects. Journal of Thrombosis and Haemostasis. https://doi.org/10.1111/j.1538-7836.2005.01305.x
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