Reg, first isolated from a rat regenerating islet cDNA library, is expressed in regenerating islet β-cells. Recently, it has been revealed that Reg and Reg-related genes constitute a multigene family, the Reg family. In human, the four REG family genes, i.e., REG Iα, REG Iβ, REG-related sequence (RS) and HIPIPAP, have so far been isolated. In this study, we analyzed YAC clones containing the four genes and performed two-color FISH to determine the map order of the genes. The human REG family genes are tandemly ordered in the 95-kbp DNA region of chromosome 2p12 as follows: 2cen-HIPIPAP-RS-REG Iα-REG Iβ-ptel. © 1995 Federation of European Biochemical Societies. All rights reserved.
Miyashita, H., Nakagawara, K. ichi, Mori, M., Narushima, Y., Noguchi, N., Moriizumi, S., … Okamoto, H. (1995). Human REG family genes are tandemly ordered in a 95-kilobase region of chromosome 2p12. FEBS Letters, 377(3), 429–433. https://doi.org/10.1016/0014-5793(95)01381-4