Following measles virus (MV) infection, host innate immune responses promptly operate to purge the virus. Detection of alerting measles viral components or replication intermediates by pattern-recognizing host machinery of Toll-like receptors and RNA helicases triggers signaling to synthesize array of anti-viral and immunoregulatory molecules, including type I interferon (IFN). Diverse subtypes of dendritic cells (DCs) play pivotal roles in both host innate immunity on the pri mary MV-infected site and initiating adaptive immune responses on secondary lymphoid tissues. Responding to the predictable host immune responses, MV appears to have devised multiple strategies to evade, suppress, or even utilize host innate immunity and DC responses. This review focuses on versatile actions of MV-induced type I IFNs causing beneficial or deleterious influence on host immu nity and the interplay between MV and heterogeneous DCs at distinct locations. © 2009 Springer.
CITATION STYLE
Hahm, B. (2009). Hostile communication of measles virus with host innate immunity and dendritic cells. Current Topics in Microbiology and Immunology. https://doi.org/10.1007/978-3-540-70617-5_13
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