Abstract
We evaluated the associations between potentially functional variants in a comprehensive list of cancer-related genes and lung cancer in a Korean population. A total of 1969 potentially functional single nucleotide polymorphisms (SNPs) of 1151 genes involved in carcinogenesis were evaluated using an Affymetrix custom-made GeneChip in 610 nonsmall cell lung cancer patients and 610 healthy controls. A replication study was conducted in an independent set of 490 cases and 486 controls. 68 SNPs were significantly associated with lung cancer in the discovery set and tested for replication. Among the 68 SNPs, three SNPs (corepressor interacting with RBPJ 1 (CIR1) rs13009079T
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CITATION STYLE
Yup Lee, S., Kang, H. G., Eun Choi, J., Kju Jung, D., Kee Lee, W., Chul Lee, H., … Yong Park, J. (2016). Polymorphisms in cancer-related pathway genes and lung cancer. European Respiratory Journal, 48(4), 1184–1191. https://doi.org/10.1183/13993003.02040-2015
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