Convenient syntheses of new quinoline nucleosides bearing amino acid esters

Abstract

Quinoline reverse nucleosides 4, 5 were prepared by reaction of quinolines 1, 2 with methyl 2,3-O-isopropylidene-5-O-p-toluenesulfonyl-β-D- ribofuranoside (3) in the presence of sodium hydride. Quinoline nucleosides bearing an amino acid ester residue 12-16 were prepared by azide coupling method from ester 4. The synthesized compounds were characterized by elemental analysis, MALDI MS and NMR data. © ARKAT USA, Inc.