The haemolytic uraemic syndrome: a family study

Abstract

This study included 6 patients, all relatives with the haemolytic uraemic syndrome, and 18 family members. The diagnosis was uncertain in one patient, probable in one other and definite in 4 patients. Three of these 4 comprised a father and 2 of his children. Data are presented to emphasize the widespread nature of the disease. Other than hypertension, predisposing factors, and red cell and HL-A genetic markers, although sought, have not been found. Management is discussed with special reference to the one surviving patient. Early bilateral nephrectomy may be life saving.