A Case of Basaloid-Squamous Carcinoma of the Larynx

Abstract

Basaloid-squamous carcinoma (BSC) is a high grade, aggressive variant of squamous cell carcinoma (SCC). The incidence of BSC of the head and neck generally has been low, although the number of case reports has increased in recent years. We report a case of BSC localized in the larynx. The biopsy specimen of the larynx suggested SCC initially, but further biopsy ultimately revealed BSC, subsequent endoscopy revealed simultaneous SCC in the esophagus. The patient was treated with surgical resection of the larynx, hypopharynx, and esophagus, and dissection of the neck bilaterally. However, bilateral lung metastasis appeared 3 months after surgery, and he died 5 months later. BSC of the head and neck region is a highly malignant neoplasm with frequent metastatic complication. Therefore, it is important to distinguish BSC from conventional SCC. Even if it is an early stage, in addition to resection of the primary neoplasm and dissection of the neck, it is essential to perform powerful whole body treatment.