Our ability to harness tolerance mechanisms will have a major impact in organ transplantation if it becomes possible to minimize drug maintenance, or even wean off immunosuppressive drugs. An improved understanding of the biology of regulatory T cells will make it possible to replace current induction regimens with those favouring the vaccination and selection of T cells that prevent graft rejection. Once tolerance is established, the continuous supply of graft antigens should sustain T cell mediated regulation as the dominant mechanism preventing graft rejection. © Springer-Verlag Berlin Heidelberg 2005.
CITATION STYLE
Waldmann, H., Graca, L., Adams, E., Fairchild, P., & Cobbold, S. (2005). Regulatory T cells in transplantation tolerance. Current Topics in Microbiology and Immunology. Springer Verlag. https://doi.org/10.1007/3-540-27702-1_11
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