Continuous positive airway pressure in patients with obstructive sleep apnea and non-alcoholic steatohepatitis: A systematic review and meta-analysis

Abstract

Study Objectives: Several studies have reported an association between obstructive sleep apnea (OSA) and several extra-pulmonary issues, such as arterial hypertension and insulin resistance. In recent years, the associations between OSA, non-alcoholic fatty liver disease, and non-alcoholic steatohepatitis (NASH) have been published; however, there is a gap between experimental and clinical studies regarding the efficacy of continuous positive airway pressure (CPAP) treatment in patient populations with these conditions. This issue should be considered when deciding on CPAP treatment in patients with OSA, especially in patients with moderate OSA. Methods: We performed a systematic review and meta-analysis of randomized controlled trials (RCTs) using the following databases: MEDLINE, Lilacs, and CENTRAL. Two independent reviewers performed the search, analysis, data extraction, and critical analysis. Results: From 622 identified studies, we included 5 RCTs that involved patients with OSA and NASH and who were treated with a CPAP device. After CPAP treatment, no changes in liver steatosis, liver fibrosis, and aminotransferase levels (alanine aminotransferase and aspartate aminotransferase) were found. Finally, the quality of evidence using the GRADE approach was low and very low for several outcomes. Conclusions: According to the current analysis, no data regarding the efficacy of CPAP in patients with NASH are available to make recommendations. Systematic Review Registration: PROSPERO; ID: CRD42015027981; URL: https://www.crd.york.ac.UK/PROSPERO/display-record. php?ID=CRD42015027981.