A family history of serious complications due to BCG vaccination is a tool for the early diagnosis of severe primary immunodeficiency

16Citations
Citations of this article
62Readers
Mendeley users who have this article in their library.

This article is free to access.

Abstract

Severe Combined Immunodeficiency (SCID) is one of the most severe forms of primary immunodeficiency (PID). Complications of BCG vaccination, especially disseminated infection and its most severe forms, are known to occur in immunodeficient patients, particularly in SCID. A carefully taken family history before BCG injection as well as delaying vaccination if PID is suspected could be a simple and effective method to avoid inappropriate vaccination of an immunodeficient child in some cases until the prospect of newborn screening for SCID has been fully developed. We describe a patient with a very early diagnosis of SCID, which was suspected on the basis of the previous death of two siblings younger than one year due to severe complications secondary to the BCG vaccine. We suggest that a family history of severe or fatal reactions to BCG should be included as a warning sign for an early diagnosis of SCID. © 2013 Roxo-Junior et al.; licensee BioMed Central Ltd.

Author supplied keywords

Cite

CITATION STYLE

APA

Roxo-Junior, P., Silva, J., Andrea, M., Oliveira, L., Ramalho, F., Bezerra, T., & Nunes, A. A. (2013). A family history of serious complications due to BCG vaccination is a tool for the early diagnosis of severe primary immunodeficiency. Italian Journal of Pediatrics. https://doi.org/10.1186/1824-7288-39-54

Register to see more suggestions

Mendeley helps you to discover research relevant for your work.

Already have an account?

Save time finding and organizing research with Mendeley

Sign up for free