The Local Effect of Chlorhexidine Agents in The Treatment of Chronic Periodontitis Patients

Abstract

Background: Periodontitis is an immuno-inflammatory disease of the tissues surrounding the teeth. Various treatment modalities like mechanical debridement and use of antimicrobials have been followed in the treatment of such conditions. Introduction of local drug delivery system in the periodontal pocket is a promising therapeutic modality for achieving better clinical outcomes when used as an adjunct to conventional non-surgical periodontal therapy. objectives: To evaluate clinical effect of different local delivery chlorhexidine Periochips and solution agents as adjuncts to SRP as combined therapy in patients with chronic periodontitis. Materials and methods: A Clinical comparative study was conducted on 45 patients of both gender (male and female) with an age of 30-50 years and with chronic moderate to severe periodontist, all patients are being undergone full-mouth mechanical debridement by using ultrasonic scaler and universal and Gracey curettes. Periodondontal pockets are to be irrigated by distillate water. Then the subjects were divided into two main group; first group consist of 15 patients with chronic periodontitis treated by chlorhexidine periochips, second group consist of 15 patients with chronic periodontitis treated by chlorhexidine Solution In addition to control group consist of 15 patients which were treated by SPR only. The criteria for chronic periodontitis was defined by the presences of PPD≥5mm and CAL≥3, in two or more different sites for each patient of at least two teeth in each quadrant, and then the results were analyzed statistically. Results: The most significant improvements were found concerning CAL, PI and GI in the group treated with CHX solution over CHX periochips (P < 0. 05), over three months. Regarding PPD, there were no significant differences in PPD reduction gain in between the two agents (P > 0. 05). Conclusion: Results of this study favor combination therapy using CHX solution as an adjunct to SRP due to greater improvement in periodontal condition of patients with chronic periodontitis, compared to those obtained by SRP alone or with SRP and CHX periochips.