Nanobiodevices for genome analysis, proteome analysis, and biomedical applications

Abstract

Nanobiodevices are developed to analyze biomolecules and cells for genome and proteome analysis. In this article, I describe numerous advantages of nanobiodevices, especially in biological, medical, and clinical applications. I also describe the development of a nanopillar device for the ultrafast separation of DNA and nanoball materials for the fast separation of wide range of DNA fragments. Bacterial cellulose is applied to the separation of DNA and SNPs (single nucleotide polymorphism) analysis of cancer genes for diagnosis of cancer. I developed a new synthetic method for quantum dots (QDs) based on appropriate cluster confirmation by ab initio molecular orbital calculation. QDs are applied to the screening of siRNA, highly sensitive detection of disease related proteins, and development of theranostic device for cancer diagnosis and therapy. Because of the high efficiency of nanobiodevices in the biomolecular and cellular analysis, numerous types of nanobiodevices are developed and applied to the diagnosis of diseases, including cancer, diabetes, hypertension, and infectious diseases. © 2011 The Chemical Society of Japan.